Trans-splenic Access for Portal Venous Interventions in Children: Do Benefits Outweigh Risks?

Sheena Pimpalwar, Ponraj Chinnadurai, Alberto Hernandez, Kamlesh Kukreja, Shakeel Siddiqui, Henri Justino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The primary concern of trans-splenic access for portal interventions is the risk of life-threatening intraperitoneal bleeding. Objective: To review the clinical indications and efficacy and evaluate the risk factors for intraperitoneal bleeding during trans-splenic portal interventions in children. Materials and Methods: A retrospective review of consecutive patients who underwent trans-splenic portal interventions at a tertiary care pediatric institution between March 2011 and April 2017 was performed. Forty-four procedures were performed in 30 children with a median age of 5 (0.3–18) years. Clinical indications, technical success, procedural success, and incidence of complications were recorded. Potential risk factors for intraperitoneal bleeding were evaluated using Wilcoxon rank and Fisher’s exact tests. Results: Trans-splenic access was 100% successful. In 35/44 (79%) procedures, the subsequent intervention was successful including recanalization of post-transplant portal vein occlusion in 10/13, embolization of bleeding Roux limb varices in 8/8, recanalization of chronic portal vein thrombosis in native liver in 7/13, splenoportography and manometry in 6/6, and occlusion of portosystemic shunts in 4/4 procedures. Intraperitoneal bleeding occurred during 12/44 (27%) procedures and was managed with analgesics, blood transfusion, and peritoneal drainage without the need for splenectomy or splenic artery embolization. Statistically significant correlation of bleeding was found with intraprocedural anticoagulation, but not with patient age, weight, platelet count, INR, ascites, splenic length, splenic venous pressure, vascular sheath size, or tract embolization technique. Conclusion: Trans-splenic access is a useful technique for successful pediatric portal interventions. Although it entails a substantial risk of intraperitoneal bleeding, this can be managed conservatively.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalCardiovascular and Interventional Radiology
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Hemorrhage
Portal Vein
Portography
Pediatrics
Surgical Portasystemic Shunt
Splenic Artery
Venous Pressure
International Normalized Ratio
Manometry
Varicose Veins
Splenectomy
Tertiary Healthcare
Platelet Count
Ascites
Blood Transfusion
Blood Vessels
Analgesics
Drainage
Thrombosis
Extremities

Keywords

  • Gelfoam
  • Intraperitoneal bleeding
  • Microfibrillar collagen
  • Portal hypertension
  • Portal vein intervention
  • Portal vein occlusion
  • Splenoportography
  • Trans-splenic access

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Trans-splenic Access for Portal Venous Interventions in Children : Do Benefits Outweigh Risks? / Pimpalwar, Sheena; Chinnadurai, Ponraj; Hernandez, Alberto; Kukreja, Kamlesh; Siddiqui, Shakeel; Justino, Henri.

In: Cardiovascular and Interventional Radiology, Vol. 41, No. 1, 01.01.2018, p. 87-95.

Research output: Contribution to journalArticle

Pimpalwar, Sheena ; Chinnadurai, Ponraj ; Hernandez, Alberto ; Kukreja, Kamlesh ; Siddiqui, Shakeel ; Justino, Henri. / Trans-splenic Access for Portal Venous Interventions in Children : Do Benefits Outweigh Risks?. In: Cardiovascular and Interventional Radiology. 2018 ; Vol. 41, No. 1. pp. 87-95.
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T1 - Trans-splenic Access for Portal Venous Interventions in Children

T2 - Do Benefits Outweigh Risks?

AU - Pimpalwar, Sheena

AU - Chinnadurai, Ponraj

AU - Hernandez, Alberto

AU - Kukreja, Kamlesh

AU - Siddiqui, Shakeel

AU - Justino, Henri

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N2 - Background: The primary concern of trans-splenic access for portal interventions is the risk of life-threatening intraperitoneal bleeding. Objective: To review the clinical indications and efficacy and evaluate the risk factors for intraperitoneal bleeding during trans-splenic portal interventions in children. Materials and Methods: A retrospective review of consecutive patients who underwent trans-splenic portal interventions at a tertiary care pediatric institution between March 2011 and April 2017 was performed. Forty-four procedures were performed in 30 children with a median age of 5 (0.3–18) years. Clinical indications, technical success, procedural success, and incidence of complications were recorded. Potential risk factors for intraperitoneal bleeding were evaluated using Wilcoxon rank and Fisher’s exact tests. Results: Trans-splenic access was 100% successful. In 35/44 (79%) procedures, the subsequent intervention was successful including recanalization of post-transplant portal vein occlusion in 10/13, embolization of bleeding Roux limb varices in 8/8, recanalization of chronic portal vein thrombosis in native liver in 7/13, splenoportography and manometry in 6/6, and occlusion of portosystemic shunts in 4/4 procedures. Intraperitoneal bleeding occurred during 12/44 (27%) procedures and was managed with analgesics, blood transfusion, and peritoneal drainage without the need for splenectomy or splenic artery embolization. Statistically significant correlation of bleeding was found with intraprocedural anticoagulation, but not with patient age, weight, platelet count, INR, ascites, splenic length, splenic venous pressure, vascular sheath size, or tract embolization technique. Conclusion: Trans-splenic access is a useful technique for successful pediatric portal interventions. Although it entails a substantial risk of intraperitoneal bleeding, this can be managed conservatively.

AB - Background: The primary concern of trans-splenic access for portal interventions is the risk of life-threatening intraperitoneal bleeding. Objective: To review the clinical indications and efficacy and evaluate the risk factors for intraperitoneal bleeding during trans-splenic portal interventions in children. Materials and Methods: A retrospective review of consecutive patients who underwent trans-splenic portal interventions at a tertiary care pediatric institution between March 2011 and April 2017 was performed. Forty-four procedures were performed in 30 children with a median age of 5 (0.3–18) years. Clinical indications, technical success, procedural success, and incidence of complications were recorded. Potential risk factors for intraperitoneal bleeding were evaluated using Wilcoxon rank and Fisher’s exact tests. Results: Trans-splenic access was 100% successful. In 35/44 (79%) procedures, the subsequent intervention was successful including recanalization of post-transplant portal vein occlusion in 10/13, embolization of bleeding Roux limb varices in 8/8, recanalization of chronic portal vein thrombosis in native liver in 7/13, splenoportography and manometry in 6/6, and occlusion of portosystemic shunts in 4/4 procedures. Intraperitoneal bleeding occurred during 12/44 (27%) procedures and was managed with analgesics, blood transfusion, and peritoneal drainage without the need for splenectomy or splenic artery embolization. Statistically significant correlation of bleeding was found with intraprocedural anticoagulation, but not with patient age, weight, platelet count, INR, ascites, splenic length, splenic venous pressure, vascular sheath size, or tract embolization technique. Conclusion: Trans-splenic access is a useful technique for successful pediatric portal interventions. Although it entails a substantial risk of intraperitoneal bleeding, this can be managed conservatively.

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KW - Microfibrillar collagen

KW - Portal hypertension

KW - Portal vein intervention

KW - Portal vein occlusion

KW - Splenoportography

KW - Trans-splenic access

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