Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

Jean Francois H Geschwind; Douglas E. Ramsey; Berry Cleffken; B. C H Van der Wal; Hicham Kobeiter; Krishna Juluru; George G. Hartnell; Michael A. Choti

doi:10.1007/s00270-002-2524-6

Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

Jean Francois H Geschwind, Douglas E. Ramsey, Berry Cleffken, B. C H Van der Wal, Hicham Kobeiter, Krishna Juluru, George G. Hartnell, Michael A. Choti

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.

Original language	English (US)
Pages (from-to)	111-117
Number of pages	7
Journal	Cardiovascular and Interventional Radiology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s00270-002-2524-6
State	Published - Mar 2003

Keywords

Angiography
Arteries
Blood supply
Chemotherapeutic embolization
Embolic material
Liver neoplasms

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/s00270-002-2524-6

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Geschwind, J. F. H., Ramsey, D. E., Cleffken, B., Van der Wal, B. C. H., Kobeiter, H., Juluru, K., Hartnell, G. G., & Choti, M. A. (2003). Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovascular and Interventional Radiology, 26(2), 111-117. https://doi.org/10.1007/s00270-002-2524-6

Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. / Geschwind, Jean Francois H; Ramsey, Douglas E.; Cleffken, Berry et al.
In: Cardiovascular and Interventional Radiology, Vol. 26, No. 2, 03.2003, p. 111-117.

Research output: Contribution to journal › Article › peer-review

Geschwind, JFH, Ramsey, DE, Cleffken, B, Van der Wal, BCH, Kobeiter, H, Juluru, K, Hartnell, GG & Choti, MA 2003, 'Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency', Cardiovascular and Interventional Radiology, vol. 26, no. 2, pp. 111-117. https://doi.org/10.1007/s00270-002-2524-6

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abstract = "The purpose of this study was to determine whether transcatheter arterial chemoembolization (TACE) protocol affects the total volume of chemotherapy injected into the liver as well as subsequent arterial patency. A total of 160 patients with primary or secondary liver cancer were treated with 3 different chemoembolization protocols at a single institution. Data were analyzed retrospectively. Group 1 (n = 36) consisted of slurry of chemotherapy, oil and polyvinyl alcohol particles (PVA), group 2 (n = 91), chemotherapy and oil followed by PVA, and group 3 (n = 33), chemotherapy and oil followed by Gelfoam pledgets. The total volume of chemotherapy injected into the liver was recorded. Arterial patency was determined during subsequent chemoembolizations. The mean percentage of total intended chemotherapy dose administered was 54.6% for group 1, 75.3% for group 2, and 80.6% for group 3. Arterial patency at follow-up angiography was 56% for group 1, 74% for group 2, and 81% for group 3. The slurry protocol (group 1) significantly reduced arterial patency and injectable volume of chemotherapy during TACE.",

keywords = "Angiography, Arteries, Blood supply, Chemotherapeutic embolization, Embolic material, Liver neoplasms",

author = "Geschwind, {Jean Francois H} and Ramsey, {Douglas E.} and Berry Cleffken and {Van der Wal}, {B. C H} and Hicham Kobeiter and Krishna Juluru and Hartnell, {George G.} and Choti, {Michael A.}",

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Transcatheter arterial chemoembolization of liver tumors: Effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency

Abstract

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