Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial

Steven G. Pavlakis; Renée C. Rees; Xiangke Huang; R. Clark Brown; James F. Casella; Rathi V. Iyer; Ram Kalpatthi; Judy Luden; Scott T. Miller; Zora R. Rogers; Courtney D. Thornburg; Winfred C. Wang; Robert J. Adams

doi:10.1002/pbc.22282

Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial

Steven G. Pavlakis, Renée C. Rees, Xiangke Huang, R. Clark Brown, James F. Casella, Rathi V. Iyer, Ram Kalpatthi, Judy Luden, Scott T. Miller, Zora R. Rogers, Courtney D. Thornburg, Winfred C. Wang, Robert J. Adams

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35 Scopus citations

Abstract

Background. Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years. Procedure. TCD was performed on infants with SCA enrolled in the BABY HUG trial. Subjects were 7-17 months of age (mean 12.6 months). TCD examinations were successfully performed in 94% of subjects (n=192). Results. No patient had an abnormal TCD as defined in the older child (time averaged maximum mean TAMM velocity ≥200 cm/sec) and only four subjects (2%) had velocities in the conditional range (170-199 cm/sec). TCD velocities were inversely related to hemoglobin (Hb) concentration and directly related to increasing age. Conclusion. Determination of whether the TCD values in this very young cohort of infants with SCA can be used to predict stroke risk later in childhood will require analysis of exit TCD's and long-term follow-up, which is ongoing (ClinicalTrials.gov number, NCT00006400).

Original language	English (US)
Pages (from-to)	256-259
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	54
Issue number	2
DOIs	https://doi.org/10.1002/pbc.22282
State	Published - Feb 2010

Keywords

Infant
Sickle cell anemia
Stroke
TCD
Transcranial doppler ultrasonography

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.22282

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Pavlakis, S. G., Rees, R. C., Huang, X., Brown, R. C., Casella, J. F., Iyer, R. V., Kalpatthi, R., Luden, J., Miller, S. T., Rogers, Z. R., Thornburg, C. D., Wang, W. C., & Adams, R. J. (2010). Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial. Pediatric Blood and Cancer, 54(2), 256-259. https://doi.org/10.1002/pbc.22282

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title = "Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial",

abstract = "Background. Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years. Procedure. TCD was performed on infants with SCA enrolled in the BABY HUG trial. Subjects were 7-17 months of age (mean 12.6 months). TCD examinations were successfully performed in 94% of subjects (n=192). Results. No patient had an abnormal TCD as defined in the older child (time averaged maximum mean TAMM velocity ≥200 cm/sec) and only four subjects (2%) had velocities in the conditional range (170-199 cm/sec). TCD velocities were inversely related to hemoglobin (Hb) concentration and directly related to increasing age. Conclusion. Determination of whether the TCD values in this very young cohort of infants with SCA can be used to predict stroke risk later in childhood will require analysis of exit TCD's and long-term follow-up, which is ongoing (ClinicalTrials.gov number, NCT00006400).",

keywords = "Infant, Sickle cell anemia, Stroke, TCD, Transcranial doppler ultrasonography",

author = "Pavlakis, {Steven G.} and Rees, {Ren{\'e}e C.} and Xiangke Huang and Brown, {R. Clark} and Casella, {James F.} and Iyer, {Rathi V.} and Ram Kalpatthi and Judy Luden and Miller, {Scott T.} and Rogers, {Zora R.} and Thornburg, {Courtney D.} and Wang, {Winfred C.} and Adams, {Robert J.}",

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doi = "10.1002/pbc.22282",

language = "English (US)",

volume = "54",

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AU - Pavlakis, Steven G.

AU - Rees, Renée C.

AU - Huang, Xiangke

AU - Brown, R. Clark

AU - Casella, James F.

AU - Iyer, Rathi V.

AU - Kalpatthi, Ram

AU - Luden, Judy

AU - Miller, Scott T.

AU - Rogers, Zora R.

AU - Thornburg, Courtney D.

AU - Wang, Winfred C.

AU - Adams, Robert J.

PY - 2010/2

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N2 - Background. Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years. Procedure. TCD was performed on infants with SCA enrolled in the BABY HUG trial. Subjects were 7-17 months of age (mean 12.6 months). TCD examinations were successfully performed in 94% of subjects (n=192). Results. No patient had an abnormal TCD as defined in the older child (time averaged maximum mean TAMM velocity ≥200 cm/sec) and only four subjects (2%) had velocities in the conditional range (170-199 cm/sec). TCD velocities were inversely related to hemoglobin (Hb) concentration and directly related to increasing age. Conclusion. Determination of whether the TCD values in this very young cohort of infants with SCA can be used to predict stroke risk later in childhood will require analysis of exit TCD's and long-term follow-up, which is ongoing (ClinicalTrials.gov number, NCT00006400).

AB - Background. Transcranial Doppler ultrasonography (TCD) is used to predict stroke risk in children with sickle cell anemia (SCA), but has not been adequately studied in children under age 2 years. Procedure. TCD was performed on infants with SCA enrolled in the BABY HUG trial. Subjects were 7-17 months of age (mean 12.6 months). TCD examinations were successfully performed in 94% of subjects (n=192). Results. No patient had an abnormal TCD as defined in the older child (time averaged maximum mean TAMM velocity ≥200 cm/sec) and only four subjects (2%) had velocities in the conditional range (170-199 cm/sec). TCD velocities were inversely related to hemoglobin (Hb) concentration and directly related to increasing age. Conclusion. Determination of whether the TCD values in this very young cohort of infants with SCA can be used to predict stroke risk later in childhood will require analysis of exit TCD's and long-term follow-up, which is ongoing (ClinicalTrials.gov number, NCT00006400).

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Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial

Abstract

Keywords

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