Transcript secondary structures regulate transcription termination at the attenuator of S. marcescens tryptophan operon

I. Stroynowski, C. Yanofsky

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We have analysed the regulatory behaviour of deletion mutants lacking different segments of the leader region of the tryptophan operon of Serratia marcescens. Our results support the model in which a particular RNA structure, the terminator, is recognized during transcription as a transcription termination signal, and an alternative RNA structure, the anti-terminator, prevents formation of the terminator. It appears that the role of translation, ribosome stalling and shifts between alternative RNA secondary structures, is simply to regulate formation of the terminator.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalNature
Volume298
Issue number5869
DOIs
StatePublished - Dec 1 1982

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this