Transcription and nucleotide excision repair - reflections, considerations and recent biochemical insights

Errol C. Friedberg, A. Jane Bardwell, Lee Bardwell, Zhigang Wang, Grigory Dianov

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Recent years have witnessed considerable progress in the definition of the preferential repair of actively transcribed genes. Equally impressive progress has been achieved in our understanding of the genetic and biochemical complexity of the DNA-repair process called nucleotide excision repair (NER). Most recently studies in several laboratories have yielded observations which provide insights about how the processes of transcription and NER may be linked in prokaryotic and eukaryotic cells.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume307
Issue number1
DOIs
StatePublished - May 1 1994

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Keywords

  • NER
  • Nucleotide excision repair
  • Transcribed genes
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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