Transcription control by long non-coding RNAs

Tyler Faust, Alan D. Frankel, Iván D'Orso

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Non-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory roles in many transcriptional programs. Here we discuss how they are targeted to promoters in several cases and how they operate at specific points in the transcription cycle to precisely control gene expression.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalTranscription
Volume3
Issue number2
DOIs
Publication statusPublished - Mar 2012

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Keywords

  • Chromatin
  • Epigenetic silencing
  • Large intergenic non-coding RNAs
  • Long non-coding RNAs
  • RNA polymerase ii
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics

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