@article{1a6de01ac17f49cead132d99bf6641b5,
title = "Transcription control by long non-coding RNAs",
abstract = "Non-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory roles in many transcriptional programs. Here we discuss how they are targeted to promoters in several cases and how they operate at specific points in the transcription cycle to precisely control gene expression.",
keywords = "Chromatin, Epigenetic silencing, Large intergenic non-coding RNAs, Long non-coding RNAs, RNA polymerase ii, Transcription",
author = "Tyler Faust and Frankel, {Alan D.} and Iv{\'a}n D'Orso",
note = "Funding Information: 7SK snRNA is enriched in nuclear speck les, a subnuclear domain rich in pre- mRNA processing factors, from which it can be recruited to sites of active transcription. In situ hybridization experiments revealed that 7SK transiently associates with a stably integrated reporter gene within minutes of inducing transcriptional repression and displaces P-TEFb from the locus. An interesting model is that the 7SK snRNP is dynamically recruited from While our understanding of the mechanistic details is still at an early stage, it seems that lncRNAs can already be considered another class of transcription factor, along with chromatin modifiers, DNA-binding regulators and other cofactors. Even though the model of lncRNAs acting as molecular scaffolds is tempting, only a few examples have been described. Additionally, the step of the transcription cycle targeted by certain lncRNAs is currently unclear. An example is the recent discovery of lincRNA-p21 and PANDA which function by assembling with We thank Cheng-Ming Chiang and Nicholas Conrad for their invaluable comments and suggestions. We apologize for the non-comprehensive nature of this review and to colleagues whose work could not be cited due to space constraints. This work was supported by NIH grants R00AI083087 (I.D.) and GM082250 (A.D.F.).",
year = "2012",
doi = "10.4161/trns.19349",
language = "English (US)",
volume = "3",
pages = "78--86",
journal = "Transcription",
issn = "2154-1264",
publisher = "Friedrich-Berlin-Verlag",
number = "2",
}