Transcription-factor-dependent control of adult hippocampal neurogenesis

Ruth Beckervordersandforth, Chun Li Zhang, Dieter Chichung Lie

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Adult-generated dentate granule neurons have emerged as major contributors to hippocampal plasticity. Newneurons are generated fromneural stem cells through a complex sequence of proliferation, differentiation, and maturation steps. Development of the new neuron is dependent on the precise temporal activity of transcription factors, which coordinate the expression of stage-specific genetic programs. Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli. Understanding transcription factor-mediated control of neuronal development will provide new insights into the mechanisms underlying neurogenesis-dependent plasticity in health and disease.

Original languageEnglish (US)
Article numbera018879
JournalCold Spring Harbor perspectives in biology
Volume7
Issue number10
DOIs
StatePublished - Oct 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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