Transcription initiated by RNA polymerase II and purified transcription factors from liver. A complex set of promoter sequences governs formation of the initial complex

J. W. Conaway, E. Travis, R. C. Conaway

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Using a transcription system derived from rat liver, we have investigated the function of the TATA-box and cap site/initiator regions in assembly of stable intermediates on the pathway leading to formation of a functional RNA polymerase II preinitiation complex. Our findings argue that neither the TATA-box region nor the cap site/initiator region functions independently in the binding of transcription factors during formation of these intermediates, but, rather, the two sequence elements function cooperatively to direct assembly of stable preinitiation complex at the promoter.

Original languageEnglish (US)
Pages (from-to)7564-7569
Number of pages6
JournalJournal of Biological Chemistry
Volume265
Issue number13
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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