Transcriptional architecture of the mammalian circadian clock

Research output: Contribution to journalReview article

336 Citations (Scopus)

Abstract

Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription-translation-based autoregulatory feedback loop. With the development of next-generation sequencing approaches, biochemical and genomic insights into circadian function have recently come into focus. Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling. The genomic targets of circadian clocks are pervasive and are intimately linked to the regulation of metabolism, cell growth and physiology.

Original languageEnglish (US)
Pages (from-to)164-179
Number of pages16
JournalNature Reviews Genetics
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Circadian Clocks
Physiological Phenomena
Biological Clocks
Cell Physiological Phenomena
Chromatin Assembly and Disassembly
RNA Polymerase II
Transcription Factors
Genome
Growth

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Transcriptional architecture of the mammalian circadian clock. / Takahashi, Joseph S.

In: Nature Reviews Genetics, Vol. 18, No. 3, 01.03.2017, p. 164-179.

Research output: Contribution to journalReview article

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