Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

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Abstract

The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) polymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD+-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-regulatory outcomes.

Original languageEnglish (US)
Pages (from-to)294-302
Number of pages9
JournalCurrent Opinion in Cell Biology
Volume20
Issue number3
DOIs
StatePublished - Jun 1 2008

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ASJC Scopus subject areas

  • Cell Biology

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