Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins

Brian L. Black, Eric N. Olson

Research output: Contribution to journalArticle

770 Citations (Scopus)

Abstract

Metazoans contain multiple types of muscle cells that share several common properties, including contractility, excitability, and expression of overlapping sets of muscle structural genes that mediate these functions. Recent biochemical and genetic studies have demonstrated that members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)box transcription factors play multiple roles in muscle cells to control myogenesis and morphogenesis. Like other MADS-box proteins, MEF2 proteins act combinatorially through protein-protein interactions with other transcription factors to control specific sets of target genes. Genetic studies in Drosophila have also begun to reveal the upstream elements of myogenic regulatory hierarchies that control MEF2 expression during development of skeletal, cardiac, and visceral muscle lineages. Paradoxically, MEF2 factors also regulate cell proliferation by functioning as endpoints for a variety of growth factor-regulated intracellular signaling pathways that are antagonistic to muscle differentiation. We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action.

Original languageEnglish (US)
Pages (from-to)167-196
Number of pages30
JournalAnnual Review of Cell and Developmental Biology
Volume14
DOIs
StatePublished - 1998

Fingerprint

MEF2 Transcription Factors
Muscle Development
Serum Response Factor
Transcription Factors
Muscle Cells
Proteins
Muscles
Morphogenesis
Genes
Drosophila
Molecular Biology
Intercellular Signaling Peptides and Proteins
Myocardium
Cell Proliferation

Keywords

  • Cardiac development
  • Gene expression
  • MADS-box
  • Myogenesis
  • Transcription factor

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. / Black, Brian L.; Olson, Eric N.

In: Annual Review of Cell and Developmental Biology, Vol. 14, 1998, p. 167-196.

Research output: Contribution to journalArticle

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