Transcriptional control signals of a eukaryotic protein-coding gene

Steven L. McKnight, Robert Kingsbury

Research output: Contribution to journalArticle

722 Scopus citations

Abstract

Transcriptional control signals of a model eukaryotic protein-coding gene have been identified by a new procedure of in vitro mutagenesis. This method allows small clusters of nucleotide residues to be substituted in a site-directed manner without causing the addition or deletion of other sequences. Transcription assays of a systematic series of these clustered point mutants have led to the identification of three distinct control signals located within the 105-nucleotide residues immediately upstream from the point where transcription begins.

Original languageEnglish (US)
Pages (from-to)316-324
Number of pages9
JournalScience
Volume217
Issue number4557
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • General

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