Transcriptional regulation of aromatase in placenta and ovary

Carole R. Mendelson, Bing Jiang, John M. Shelton, James A. Richardson, Margaret M. Hinshelwood

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Our goal is to define the cellular and molecular mechanisms for tissue- and cell-specific, developmental and hormonal regulation of the human CYP19 (aromatase P450/P450arom) gene in estrogen-producing cells. In this article, we review studies using transgenic mice and transfected cells to identify genomic regions and response elements that mediate CYP19 expression in placenta and ovary, as well as to define the molecular mechanisms for O2 regulation of differentiation and CYP19 gene expression in human trophoblast cells in culture. We also highlight recent findings regarding LRH-1 versus SF-1 mRNA expression and cellular localization in the mouse ovary during the estrous cycle and various stages of pregnancy. Spatial and temporal expression patterns of mRNAs encoding these orphan nuclear receptors in comparison to those of P450arom and 17α-hydroxylase/17,20-lyase mRNAs, suggest an important role of LRH-1 together with SF-1 in ovarian steroidogenesis.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume95
Issue number1-5
DOIs
StatePublished - May 2005

Keywords

  • Estrogen biosynthesis
  • Human CYP19 gene
  • Liver receptor homologue-1 (LRH-1)
  • Steroidogenic factor-1 (SF-1)
  • Tissue-specific expression

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Endocrinology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint

Dive into the research topics of 'Transcriptional regulation of aromatase in placenta and ovary'. Together they form a unique fingerprint.

Cite this