Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

Qing Lin Li, Hye Ryeon Kim, Wun Jae Kim, Joong Kook Choi, Yong Hee Lee, Hwan Mook Kim, Long Shan Li, Hoguen Kim, Joon Chang, Yoshiaki Ito, Kwang Youl Lee, Suk Chul Bae

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

RUNX family transcription factors are integral components of TGF-β signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately 19% of lung cancer cell lines and 24% of primary lung cancer specimens. RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume314
Issue number1
DOIs
StatePublished - Jan 30 2004

Keywords

  • Lung cancer
  • Methylation
  • RUNX3
  • TGF-β
  • Transcription

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Li, Q. L., Kim, H. R., Kim, W. J., Choi, J. K., Hee Lee, Y., Kim, H. M., Shan Li, L., Kim, H., Chang, J., Ito, Y., Youl Lee, K., & Bae, S. C. (2004). Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. Biochemical and Biophysical Research Communications, 314(1), 223-228. https://doi.org/10.1016/j.bbrc.2003.12.079