Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Shijia Zhu; Naoto Kubota; Yujin Hoshida

doi:10.1016/j.tig.2021.01.007

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Shijia Zhu, Naoto Kubota, Yujin Hoshida

Research output: Contribution to journal › Short survey › peer-review

Abstract

Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

Original language	English (US)
Pages (from-to)	403-404
Number of pages	2
Journal	Trends in Genetics
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.tig.2021.01.007
State	Published - May 2021

Keywords

gene regulatory network
human induced pluripotent stem cell
organogenesis

ASJC Scopus subject areas

Genetics

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10.1016/j.tig.2021.01.007

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title = "Transcriptome-Guided Design of Physiological Multilineage Liver Organoids",

abstract = "Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.",

keywords = "gene regulatory network, human induced pluripotent stem cell, organogenesis",

author = "Shijia Zhu and Naoto Kubota and Yujin Hoshida",

note = "Funding Information: This work was supported by National Institutes of Health ( DK099558 , CA233794 , and CA226052 ), European Commission ( ERC-2014-AdG-671231 ), and Cancer Prevention and Research Institute of Texas ( RR180016 ) grants to Y.H. Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = may,

doi = "10.1016/j.tig.2021.01.007",

language = "English (US)",

volume = "37",

pages = "403--404",

journal = "Trends in Genetics",

issn = "0168-9525",

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T1 - Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

AU - Zhu, Shijia

AU - Kubota, Naoto

AU - Hoshida, Yujin

N1 - Funding Information: This work was supported by National Institutes of Health ( DK099558 , CA233794 , and CA226052 ), European Commission ( ERC-2014-AdG-671231 ), and Cancer Prevention and Research Institute of Texas ( RR180016 ) grants to Y.H. Publisher Copyright: © 2021

PY - 2021/5

Y1 - 2021/5

N2 - Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

AB - Despite several technical challenges, human induced pluripotent stem cell (hiPSC)-derived organoids enable biologically and clinically relevant functional study of physiology and disease. In a recent Cell Systems article, Velazquez et al. report a novel strategy to identify regulators of multilineage organoid maturation by reverse-engineering from the global transcriptome of human tissues.

KW - gene regulatory network

KW - human induced pluripotent stem cell

KW - organogenesis

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DO - 10.1016/j.tig.2021.01.007

M3 - Short survey

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AN - SCOPUS:85100397094

SN - 0168-9525

VL - 37

SP - 403

EP - 404

JO - Trends in Genetics

JF - Trends in Genetics

IS - 5

ER -

Transcriptome-Guided Design of Physiological Multilineage Liver Organoids

Abstract

Keywords

ASJC Scopus subject areas

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