Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues

B. L. Drake, J. R. Head

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The expression of the transferrin receptor (TR) was examined on murine trophoblast cells on days 6, 8 and 10 gestation, using a monoclonal antibody visualized by indirect immunofluorescence on cryostat sections of the implant site. In the day 6 tissues, TR were observed on both the ectoplacental cone (EPC) and mural giant cell trophoblast populations, as well as on the embryonic ectoderm, anti-mesometrial decidual cells, uterine glandular epithelium and myometrium. By the 8th day of gestation, TR expression was weak, or undetectable on trophoblast giant cells (TGC), but remained strong on the proliferating cells of the EPC and embryo. In the definitive placenta (day 10), TR are expressed primarily on the differentiated labyrinthine trophoblast cells involved in the maternal-fetal transfer of iron.

Original languageEnglish (US)
Pages (from-to)535-547
Number of pages13
JournalPlacenta
Volume11
Issue number6
DOIs
StatePublished - 1990

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Transferrin Receptors
Trophoblasts
Giant Cells
Pregnancy
Ectoderm
Myometrium
Indirect Fluorescent Antibody Technique
Placenta
Embryonic Structures
Epithelium
Iron
Monoclonal Antibodies
Mothers
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues. / Drake, B. L.; Head, J. R.

In: Placenta, Vol. 11, No. 6, 1990, p. 535-547.

Research output: Contribution to journalArticle

Drake, B. L. ; Head, J. R. / Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues. In: Placenta. 1990 ; Vol. 11, No. 6. pp. 535-547.
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