Transformation of 15-hete to 14,15-dihydroxyeicosatrienoic acid and 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acid

J R Falck, S. Manna, Arup K. Siddhanta, Jorge Capdevila, John D. Buynak

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Abstract

The erythro and threo 13,14-epoxides of 15(S)-HETE were transformed to 14,15-dihydroxyeicostrienoic acid (14,15-DHET) by regiospecific reduction and to a mixture of 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acids (THET) by hydrolysis.

Original languageEnglish (US)
Pages (from-to)5715-5718
Number of pages4
JournalTetrahedron Letters
Volume24
Issue number51
DOIs
Publication statusPublished - 1983

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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