Transforming growth factor-β receptor III downregulation in prostate cancer: Is inhibin B a tumor suppressor in prostate?

Nima Sharifi; Robert J. Lechleider; William L. Farrar

doi:10.1677/JME-07-0084

Transforming growth factor-β receptor III downregulation in prostate cancer: Is inhibin B a tumor suppressor in prostate?

Nima Sharifi, Robert J. Lechleider, William L. Farrar

Internal Medicine

Research output: Contribution to journal › Comment/debate › peer-review

20 Scopus citations

Abstract

The transforming growth factor-β (TGF-β) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-β receptor III is the most common TGF-β pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.

Original language	English (US)
Pages (from-to)	329-332
Number of pages	4
Journal	Journal of molecular endocrinology
Volume	39
Issue number	5-6
DOIs	https://doi.org/10.1677/JME-07-0084
State	Published - Nov 2007

ASJC Scopus subject areas

Molecular Biology
Endocrinology

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title = "Transforming growth factor-β receptor III downregulation in prostate cancer: Is inhibin B a tumor suppressor in prostate?",

abstract = "The transforming growth factor-β (TGF-β) pathway plays dual roles in cancer, inhibiting epithelial cell growth under normal physiologic conditions, but promoting invasion and metastasis once growth inhibitory responses are lost. Two recent papers show that TGF-β receptor III is the most common TGF-β pathway component downregulated in prostate cancer. Here, we discuss the implications of these findings and what it may mean about the biology of this disease.",

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Transforming growth factor-β receptor III downregulation in prostate cancer: Is inhibin B a tumor suppressor in prostate?

Abstract

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