Abstract
Endothelin is a potent vasoconstrictor peptide produced by vascular endothelial cells. Incubation of the serum-deprived confluent porcine aortic endothelial cells with 10-300 pM TGF-β1, resulted in a several fold increase in endothelin mRNA levels with a peak time of 2 h. An enzyme-linked immunosorbent assay revealed that the levels of endothelin in endothelial cell conditioned media was also increased by TGF-β1. These results suggest that TGF-β1, secreted by activated platelets, is involved not only in wound healing, but in the regulation of local vascular tone by stimulating endothelin production in the endothelial cells.
Original language | English (US) |
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Pages (from-to) | 1435-1440 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 159 |
Issue number | 3 |
DOIs | |
State | Published - Mar 31 1989 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology