Transfusion-transmitted viral infections other than hepatitis and human immunodeficiency virus infection: Cytomegalovirus, Epstein-Barr virus, human herpesvirus 6, and human parvovirus B19

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Abstract

During the last decade, there has been a sharp increase in the number of tests routinely used to screen all volunteer whole blood donations for evidence of transfusion-transmissible infection. These measures have had a dramatic effect on improvements in transfusion safety, especially as far as hepatitis viruses and the human immunodeficiency virus are concerned. Although all blood donations are not routinely screened for evidence of possible transmissibility of cytomegalovirus, some are, since there is now a clearer understanding of the categories of patients in whom this infection must be avoided. Recent studies have also pointed to a role for leukocyte filtration of transfusion products as an alternative to donor screening for selected patients at risk of cytomegalovirus infection. With regard to other viruses, knowledge about the relevance of Epstein-Barr virus, human herpesvirus 6, and parvovirus to blood product safety is incomplete. Until their pathogenicity, if any, in transfusion recipients is known, recommendations about special handling of blood products because of concern for these viruses is premature.

Original languageEnglish (US)
Pages (from-to)346-349
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume118
Issue number4
StatePublished - 1994

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Human Parvovirus B19
Human Herpesvirus 6
Virus Diseases
Blood Donors
Cytomegalovirus
Human Herpesvirus 4
Hepatitis
Leukocyte Transfusion
HIV
Blood Safety
Viruses
Donor Selection
Hepatitis Viruses
Parvovirus
Cytomegalovirus Infections
Infection
Virulence
Volunteers
Safety

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

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abstract = "During the last decade, there has been a sharp increase in the number of tests routinely used to screen all volunteer whole blood donations for evidence of transfusion-transmissible infection. These measures have had a dramatic effect on improvements in transfusion safety, especially as far as hepatitis viruses and the human immunodeficiency virus are concerned. Although all blood donations are not routinely screened for evidence of possible transmissibility of cytomegalovirus, some are, since there is now a clearer understanding of the categories of patients in whom this infection must be avoided. Recent studies have also pointed to a role for leukocyte filtration of transfusion products as an alternative to donor screening for selected patients at risk of cytomegalovirus infection. With regard to other viruses, knowledge about the relevance of Epstein-Barr virus, human herpesvirus 6, and parvovirus to blood product safety is incomplete. Until their pathogenicity, if any, in transfusion recipients is known, recommendations about special handling of blood products because of concern for these viruses is premature.",
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