Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1

Serkan Belkaya, Sean E. Murray, Jennifer L. Eitson, M. Teresa De La Morena, James A. Forman, Nicolai S C Van Oers

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: MicroRNAs have critical roles in T cell development under normal and stress conditions. Results: Increasing miR-185 levels attenuate T cell development via the targeting of Mzb1, Nfatc3, and Camk4. Conclusion: Elevations in miR-185 impair thymopoiesis at several developmental stages. Significance: miR-185 levels are reduced in 22q11.2 deletion syndrome patients and the identification of its gene targets is clinically informative.

Original languageEnglish (US)
Pages (from-to)30752-30762
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

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T-cells
Gene Targeting
MicroRNAs
Genes
DiGeorge Syndrome
T-Lymphocytes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. / Belkaya, Serkan; Murray, Sean E.; Eitson, Jennifer L.; De La Morena, M. Teresa; Forman, James A.; Van Oers, Nicolai S C.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30752-30762.

Research output: Contribution to journalArticle

Belkaya, Serkan ; Murray, Sean E. ; Eitson, Jennifer L. ; De La Morena, M. Teresa ; Forman, James A. ; Van Oers, Nicolai S C. / Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 42. pp. 30752-30762.
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