Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1

Serkan Belkaya, Sean E. Murray, Jennifer L. Eitson, M. Teresa De La Morena, James A. Forman, Nicolai S C Van Oers

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: MicroRNAs have critical roles in T cell development under normal and stress conditions. Results: Increasing miR-185 levels attenuate T cell development via the targeting of Mzb1, Nfatc3, and Camk4. Conclusion: Elevations in miR-185 impair thymopoiesis at several developmental stages. Significance: miR-185 levels are reduced in 22q11.2 deletion syndrome patients and the identification of its gene targets is clinically informative.

Original languageEnglish (US)
Pages (from-to)30752-30762
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1'. Together they form a unique fingerprint.

  • Cite this