TY - JOUR
T1 - Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin
AU - Cha, Jeong Heon
AU - Chang, Mee Young
AU - Richardson, James A.
AU - Eidels, Leon
PY - 2003/7
Y1 - 2003/7
N2 - Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until recently. The receptor was identified by its ability to confer toxin-sensitivity to mouse cells, which are normally toxin-resistant. Although mice are also naturally resistant, we now demonstrate that transgenic mice expressing the diphtheria toxin receptor are as sensitive to the toxin as are humans and other toxin-sensitive animals. These transgenic mice provide a suitable model for studying modern antidotes for diphtheria.
AB - Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until recently. The receptor was identified by its ability to confer toxin-sensitivity to mouse cells, which are normally toxin-resistant. Although mice are also naturally resistant, we now demonstrate that transgenic mice expressing the diphtheria toxin receptor are as sensitive to the toxin as are humans and other toxin-sensitive animals. These transgenic mice provide a suitable model for studying modern antidotes for diphtheria.
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U2 - 10.1046/j.1365-2958.2003.03550.x
DO - 10.1046/j.1365-2958.2003.03550.x
M3 - Article
C2 - 12823824
AN - SCOPUS:0038046761
SN - 0950-382X
VL - 49
SP - 235
EP - 240
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 1
ER -