Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin

Jeong Heon Cha, Mee Young Chang, James A. Richardson, Leon Eidels

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Whereas diphtheria and the mechanism of action of diphtheria toxin, the bacterial molecule that induces the disease, have been studied and understood for some time, the receptor that allows animal cells to bind the toxin escaped identification until recently. The receptor was identified by its ability to confer toxin-sensitivity to mouse cells, which are normally toxin-resistant. Although mice are also naturally resistant, we now demonstrate that transgenic mice expressing the diphtheria toxin receptor are as sensitive to the toxin as are humans and other toxin-sensitive animals. These transgenic mice provide a suitable model for studying modern antidotes for diphtheria.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalMolecular Microbiology
Volume49
Issue number1
DOIs
StatePublished - Jul 1 2003

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ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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