Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes

Raymond J MacDonald, Robert E Hammer, Galvin H Swift, B. P. Davis, R. L. Brinster

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Six different lines of transgenic mice bearing rat elastase I genes stably inherit both the high-level pancreatic expression and low-level nonpancreatic expression characteristic of each original founding mouse. The high pancreatic expression of the introduced rat genes is transcriptionally determined. In response to high rat elastase I mRNA content in the pancreas, rat elastase I protein is synthesized and secreted at high levels. The stable inheritance of expression of the foreign rat elastase I genes in transgenic mice allows the development of animal lines that synthesize and secrete high levels of foreign protein by the pancreas.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalDNA
Volume5
Issue number5
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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