Abstract
Six different lines of transgenic mice bearing rat elastase I genes stably inherit both the high-level pancreatic expression and low-level nonpancreatic expression characteristic of each original founding mouse. The high pancreatic expression of the introduced rat genes is transcriptionally determined. In response to high rat elastase I mRNA content in the pancreas, rat elastase I protein is synthesized and secreted at high levels. The stable inheritance of expression of the foreign rat elastase I genes in transgenic mice allows the development of animal lines that synthesize and secrete high levels of foreign protein by the pancreas.
Original language | English (US) |
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Pages (from-to) | 393-401 |
Number of pages | 9 |
Journal | DNA |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1986 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics