Transient regenerative potential of the neonatal mouse heart

Enzo R. Porrello, Ahmed I. Mahmoud, Emma Simpson, Joseph A Hill, James A Richardson, Eric N Olson, Hesham A Sadek

Research output: Contribution to journalArticle

1137 Scopus citations

Abstract

Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early after birth has been unclear. We found that the hearts of 1-day-old neonatal mice can regenerate after partial surgical resection, but this capacity is lost by 7 days of age. This regenerative response in 1-day-old mice was characterized by cardiomyocyte proliferation with minimal hypertrophy or fibrosis, thereby distinguishing it from repair processes. Genetic fate mapping indicated that the majority of cardiomyocytes within the regenerated tissue originated from preexisting cardiomyocytes. Echocardiography performed 2 months after surgery revealed that the regenerated ventricular apex had normal systolic function. Thus, for a brief period after birth, the mammalian heart appears to have the capacity to regenerate.

Original languageEnglish (US)
Pages (from-to)1078-1080
Number of pages3
JournalScience
Volume331
Issue number6020
DOIs
StatePublished - Feb 25 2011

ASJC Scopus subject areas

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