Translation of Quantitative Imaging Biomarkers into Clinical Chest CT

Fernando Uliana Kay, Orhan K Oz, Suhny Abbara, Eduardo J. Mortani Barbosa, Prachi P. Agarwal, Prabhakar Rajiah

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Quantitative imaging has been proposed as the next frontier in radiology as part of an effort to improve patient care through precision medicine. In 2007, the Radiological Society of North America launched the Quantitative Imaging Biomarkers Alliance (QIBA), an initiative aimed at improving the value and practicality of quantitative imaging biomarkers by reducing variability across devices, sites, patients, and time. Chest CT occupies a strategic position in this initiative because it is one of the most frequently used imaging modalities, anatomically encompassing the leading causes of mortality worldwide. To date, QIBA has worked on profiles focused on the accurate, reproducible, and meaningful use of volumetric measurements of lung lesions in chest CT. However, other quantitative methods are on the verge of translation from research grounds into clinical practice, including (a) assessment of parenchymal and airway changes in patients with chronic obstructive pulmonary disease, (b) analysis of perfusion with dual-energy CT biomarkers, and (c) opportunistic screening for coronary atherosclerosis and low bone mass by using chest CT examinations performed for other indications. The rationale for and the key facts related to the application of these quantitative imaging biomarkers in cardiothoracic chest CT are presented.

Original languageEnglish (US)
Pages (from-to)957-976
Number of pages20
JournalRadiographics : a review publication of the Radiological Society of North America, Inc
Volume39
Issue number4
DOIs
StatePublished - Jul 1 2019

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Thorax
Biomarkers
Precision Medicine
Radiology
Chronic Obstructive Pulmonary Disease
Coronary Artery Disease
Patient Care
Perfusion
Bone and Bones
Equipment and Supplies
Lung
Mortality
Research

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Translation of Quantitative Imaging Biomarkers into Clinical Chest CT. / Kay, Fernando Uliana; Oz, Orhan K; Abbara, Suhny; Mortani Barbosa, Eduardo J.; Agarwal, Prachi P.; Rajiah, Prabhakar.

In: Radiographics : a review publication of the Radiological Society of North America, Inc, Vol. 39, No. 4, 01.07.2019, p. 957-976.

Research output: Contribution to journalArticle

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