Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.
- alternative translation initiation factors
- immune checkpoints
- integrated stress response (ISR) pathway
- translation regulation
ASJC Scopus subject areas
- Cancer Research