Translational Control of Immune Evasion in Cancer

Shruthy Suresh, Kathryn A. O'Donnell

Research output: Contribution to journalShort surveypeer-review

Abstract

Mechanisms that control translation play important roles in tumor progression and metastasis. Emerging evidence has revealed that dysregulated translation also impacts immune evasion in response to cellular or oncogenic stress. Here, we summarize current knowledge regarding the translational control of immune checkpoints and implications for cancer immunotherapies.

Original languageEnglish (US)
JournalTrends in Cancer
DOIs
StateAccepted/In press - 2021

Keywords

  • PD-1/PD-L1
  • alternative translation initiation factors
  • immune checkpoints
  • integrated stress response (ISR) pathway
  • translation regulation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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