Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism

Errol C. Friedberg; Lisa D. McDaniel

Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.

Original language	English (US)
Title of host publication	New Research on DNA Repair
Publisher	Nova Science Publishers, Inc.
Pages	167-190
Number of pages	24
ISBN (Print)	9781600213854
State	Published - Dec 1 2007

Keywords

Bypass polymerase
DCMP transferase
Lesion bypass
Xeroderma pigmentosum varient

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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AB - Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.

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