Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism

Errol C. Friedberg, Lisa D. McDaniel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.

Original languageEnglish (US)
Title of host publicationNew Research on DNA Repair
PublisherNova Science Publishers, Inc.
Pages167-190
Number of pages24
ISBN (Print)9781600213854
StatePublished - Dec 1 2007

Keywords

  • Bypass polymerase
  • DCMP transferase
  • Lesion bypass
  • Xeroderma pigmentosum varient

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Friedberg, E. C., & McDaniel, L. D. (2007). Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism. In New Research on DNA Repair (pp. 167-190). Nova Science Publishers, Inc..