Abstract
Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.
| Original language | English (US) |
|---|---|
| Title of host publication | New Research on DNA Repair |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 167-190 |
| Number of pages | 24 |
| ISBN (Print) | 9781600213854 |
| State | Published - 2007 |
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Keywords
- Bypass polymerase
- DCMP transferase
- Lesion bypass
- Xeroderma pigmentosum varient
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism. / Friedberg, Errol C.; McDaniel, Lisa D.
New Research on DNA Repair. Nova Science Publishers, Inc., 2007. p. 167-190.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Translesion DNA synthesis-A fundamental DNA damage tolerance mechanism
AU - Friedberg, Errol C.
AU - McDaniel, Lisa D.
PY - 2007
Y1 - 2007
N2 - Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.
AB - Translesion DNA synthesis (TLS) is a fundamental biological process whereby arrested DNA replication caused by the presence of base damage that cannot be readily bypassed by replicative DNA polymerases, is relieved by an alternative DNA replication that utilizes DNA polymerases that are specialized for DNA synthesis past such lesions. Multiple such polymerases have been identified in all life forms. In particular, vertebrate cells contain no less than 10 such specialized enzymes. This article reviews our present knowledge of these specialized DNA polymerases in general and their specific role in TLS.
KW - Bypass polymerase
KW - DCMP transferase
KW - Lesion bypass
KW - Xeroderma pigmentosum varient
UR - http://www.scopus.com/inward/record.url?scp=84895299776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895299776&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84895299776
SN - 9781600213854
SP - 167
EP - 190
BT - New Research on DNA Repair
PB - Nova Science Publishers, Inc.
ER -