Translocation t(11;22) in esthesioneuroblastoma

Jacqueline Whang-Peng, Carl E. Freter, Turid Knutsen, J. J. Nanfro, Adi Gazdar

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Abstract

Esthesioneuroblastoma is an exceedingly rare malignant neuroectodermal tumor of olfactory epithelium origin. We have performed cytogenetic studies on a tissue culture line established from a metastatic lesion in one such patient and observed that, among several chromosomal abnormalities, the cells contained a reciprocal translocation, t(11;22)(q24;q12), indistinguishable from the one that has been reported in Ewing's sarcoma, Askin's tumor, and peripheral neuroepithelioma. The uniqueness of this marker suggests that these tumors may be derived from the same type of stem cell, with varying histopathologic and clinical manifestations.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume29
Issue number1
DOIs
StatePublished - Nov 1987

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Whang-Peng, J., Freter, C. E., Knutsen, T., Nanfro, J. J., & Gazdar, A. (1987). Translocation t(11;22) in esthesioneuroblastoma. Cancer Genetics and Cytogenetics, 29(1), 155-157. https://doi.org/10.1016/0165-4608(87)90043-4