Transplantable Polyomavirus-Induced Salivary Gland Epitheliomas Are Populated by Immature T Cells Derived from the Host

Florence A. Harrod, Glenn P. Hoot, John R. Kettman

Research output: Contribution to journalArticle

Abstract

Transplantable, polyomavirus-induced salivary gland epitheliomas were passaged through F1-hybrid mice of C3H/Bittner with BALB/cJ or AKR/J strains and congenic nu/nu athymic mice on the BALB/c background. By analysis of the Thy-1 and Ly-2 (CD8a) alloantigens of the T cells that infiltrated the transplanted tumors, it has been determined that the lymphocytes were derived from the host and not the donor of the epithelial tumor. It is known that the tumor masses in the FL-hybrid and athymic mice were not the result of a secondary tumor induction or transformation of host tissue because the epithelioma could be transplanted back into the strain of origin, C3H/Bittner. Intratumor lymphocytes resembled thymocytes on the basis of their intense staining by anti-Thy-1 reagents, the presence of large fractions of cells that bore both CD4 and CD8a, and the cell-size distribution of the phenotypes. Nu/nu mice carrying epitheliomas infiltrated with host-origin T lymphocytes were not immunologically reconstituted, as judged by the lack of T cells in the spleens of such tumor hosts. The epithelial tumors acted as sites of host T-lymphocyte maturation, but the process was incomplete, and mature T cells did not emigrate to the periphery.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalCellular Immunology
Volume154
Issue number1
DOIs
StatePublished - Mar 1994

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Polyomavirus
Salivary Glands
Carcinoma
T-Lymphocytes
Neoplasms
Nude Mice
Lymphocytes
Isoantigens
Inbred C3H Mouse
Thymocytes
Cell Size
Spleen
Staining and Labeling
Phenotype

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Transplantable Polyomavirus-Induced Salivary Gland Epitheliomas Are Populated by Immature T Cells Derived from the Host. / Harrod, Florence A.; Hoot, Glenn P.; Kettman, John R.

In: Cellular Immunology, Vol. 154, No. 1, 03.1994, p. 1-13.

Research output: Contribution to journalArticle

Harrod, Florence A. ; Hoot, Glenn P. ; Kettman, John R. / Transplantable Polyomavirus-Induced Salivary Gland Epitheliomas Are Populated by Immature T Cells Derived from the Host. In: Cellular Immunology. 1994 ; Vol. 154, No. 1. pp. 1-13.
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