Transporters Revealed

Jyh Yeuan Lee, Daniel M. Rosenbaum

Research output: Contribution to journalShort survey

8 Scopus citations

Abstract

The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.

Original languageEnglish (US)
Pages (from-to)951-953
Number of pages3
JournalCell
Volume168
Issue number6
DOIs
StatePublished - Mar 9 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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