Transporters Revealed

Jyh Yeuan Lee; Daniel M. Rosenbaum

doi:10.1016/j.cell.2017.02.033

Transporters Revealed

Jyh Yeuan Lee, Daniel M. Rosenbaum

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.

Original language	English (US)
Pages (from-to)	951-953
Number of pages	3
Journal	Cell
Volume	168
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2017.02.033
State	Published - Mar 9 2017

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2017.02.033

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abstract = "The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of this ABC transporter subfamily.",

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AU - Rosenbaum, Daniel M.

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Transporters Revealed

Abstract

ASJC Scopus subject areas

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