Transverse Myelitis

Shin C Beh; Benjamin Greenberg; Teresa Frohman; Elliot Frohman

doi:10.1016/j.ncl.2012.09.008

Transverse Myelitis

Shin C Beh, Benjamin Greenberg, Teresa Frohman, Elliot Frohman

Research output: Contribution to journal › Review article › peer-review

147 Scopus citations

Abstract

Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and acquired demyelinating diseases. We discuss the clinical evaluation, workup, and acute and long-term management of patients with TM. Additionally, we briefly discuss various disease entities that may cause TM and their salient distinguishing features, as well as disorders that may mimic TM.

Original language	English (US)
Pages (from-to)	79-138
Number of pages	60
Journal	Neurologic Clinics
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.ncl.2012.09.008
State	Published - Feb 2013

Keywords

Idiopathic transverse myelitis
Longitudinally-extensive transverse myelitis
Lupus myelopathy
Multiple sclerosis
Sjogren's myelopathy
Transverse myelitis

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2012.09.008

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title = "Transverse Myelitis",

abstract = "Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and acquired demyelinating diseases. We discuss the clinical evaluation, workup, and acute and long-term management of patients with TM. Additionally, we briefly discuss various disease entities that may cause TM and their salient distinguishing features, as well as disorders that may mimic TM.",

keywords = "Idiopathic transverse myelitis, Longitudinally-extensive transverse myelitis, Lupus myelopathy, Multiple sclerosis, Sjogren's myelopathy, Transverse myelitis",

author = "Beh, {Shin C} and Benjamin Greenberg and Teresa Frohman and Elliot Frohman",

note = "Funding Information: Disclosures & Conflicts of Interest: Dr Beh is the recipient of the Biogen Idec Clinical MS Fellowship award. Dr Greenberg has received honoraria from EMD Serono, American Academy of Neurology, Multiple Sclerosis Association of America, and National Multiple Sclerosis Society; consulting fees from Acorda, DioGenix, and Greater Good Foundation; and grants from Amplimmune, Accelerated Cure Project, and Guthy Jackson Charitable Foundation. Teresa Frohman is a consultant and speaker for Biogen Idec and Novartis. Dr Frohman has received speaker fees from Biogen Idec, Teva Neuroscience, and Acorda Pharmaceuticals, and consulting fees from Biogen Idec, Teva Neurosciences, Abbott, Acorda Therapeutics, and Novartis. ",

year = "2013",

month = feb,

doi = "10.1016/j.ncl.2012.09.008",

language = "English (US)",

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pages = "79--138",

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AU - Beh, Shin C

AU - Greenberg, Benjamin

AU - Frohman, Teresa

AU - Frohman, Elliot

N1 - Funding Information: Disclosures & Conflicts of Interest: Dr Beh is the recipient of the Biogen Idec Clinical MS Fellowship award. Dr Greenberg has received honoraria from EMD Serono, American Academy of Neurology, Multiple Sclerosis Association of America, and National Multiple Sclerosis Society; consulting fees from Acorda, DioGenix, and Greater Good Foundation; and grants from Amplimmune, Accelerated Cure Project, and Guthy Jackson Charitable Foundation. Teresa Frohman is a consultant and speaker for Biogen Idec and Novartis. Dr Frohman has received speaker fees from Biogen Idec, Teva Neuroscience, and Acorda Pharmaceuticals, and consulting fees from Biogen Idec, Teva Neurosciences, Abbott, Acorda Therapeutics, and Novartis.

PY - 2013/2

Y1 - 2013/2

N2 - Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and acquired demyelinating diseases. We discuss the clinical evaluation, workup, and acute and long-term management of patients with TM. Additionally, we briefly discuss various disease entities that may cause TM and their salient distinguishing features, as well as disorders that may mimic TM.

AB - Transverse myelitis (TM) includes a pathobiologically heterogeneous syndrome characterized by acute or subacute spinal cord dysfunction resulting in paresis, a sensory level, and autonomic (bladder, bowel, and sexual) impairment below the level of the lesion. Etiologies for TM can be broadly classified as parainfectious, paraneoplastic, drug/toxin-induced, systemic autoimmune disorders, and acquired demyelinating diseases. We discuss the clinical evaluation, workup, and acute and long-term management of patients with TM. Additionally, we briefly discuss various disease entities that may cause TM and their salient distinguishing features, as well as disorders that may mimic TM.

KW - Idiopathic transverse myelitis

KW - Longitudinally-extensive transverse myelitis

KW - Lupus myelopathy

KW - Multiple sclerosis

KW - Sjogren's myelopathy

KW - Transverse myelitis

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Transverse Myelitis

Abstract

Keywords

ASJC Scopus subject areas

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