Trastuzumab, an appropriate first-line single-agent therapy for HER2-overexpressing metastatic breast cancer

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Overexpression of the HER2/Neu (ErbB2) proto-oncogene is associated with breast cancer progression and poor patient prognosis. Herceptin (trastuzumab) is a humanized IgG1 against the ectodomain of the HER2 receptor. In combination with chemotherapy, it induces regression of HER2-overexpressing metastatic breast tumors and prolongs patient survival. Single-agent Herceptin in patients with HER2-amplified breast tumors also induces a definite objective response and clinical benefit rates, and is well tolerated. These data suggest that Herceptin is an effective first-line single-agent therapy for a predictable cohort of metastatic breast cancers and can therefore be used as a platform for therapeutic discovery against tumors that overexpress HER2.

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalBreast Cancer Research
Issue number2
Publication statusPublished - Apr 1 2003



  • Breast cancer
  • Clinical trials
  • erbB2
  • HER2/Neu
  • Herceptin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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