Trauma-Specific Brain abnormalities in suspected mild traumatic brain injury patients identified in the first 48 hours after injury

A blinded magnetic resonance imaging comparative study including suspected acute minor stroke patients

Maria Chiara Ricciardi, Reinoud P H Bokkers, John A. Butman, Dima A. Hammoud, Dzung L. Pham, Steven Warach, Lawrence L. Latour

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We assessed the utility of a brief MRI protocol, appropriate for the acute setting, to detect acute traumatic brain injury (TBI) in patients with suspected mild TBI (mTBI) and distinguish traumatic from nontraumatic brain injury by comparing trauma with nontrauma patients. Twenty-two patients with suspected mTBI were included in this exploratory study over a period of 9 months. Median time from injury to MR scanning was 5.4 h (interquartile range 3.6-15.3). To determine the specificity of certain findings for TBI, 61 patients presenting with suspected minor acute stroke were included as a comparative group using the same MRI methods. A selected series of MRI sequences (diffusion-weighted imaging, fluid attenuated inversion recovery [FLAIR], and T2∗ weighted) were independently evaluated by two neuroradiologists blinded to clinical diagnosis, for presence of specific findings. In a separate session, all cases in which at least one MRI sequence above was positive were classified as TBI, stroke, or indeterminate. Intracranial MRI abnormalities were observed in 47 (57%) of the 83 studied patients. Based on findings on MRI, 12 (55%) of 22 suspected mTBI patients were classified as having traumatic injury. Nine (47%) of the 19 suspected mTBI patients with a negative CT had findings on MRI. Abnormalities on MRI consistent with trauma were observed most frequently on postcontrast FLAIR (83%) and T2∗-weighted (58%) sequences. We demonstrated the ability of a fast MRI protocol to identify trauma-related abnormalities not seen on CT, and differentiate acute trauma from nonspecific chronic disease in a blinded cohort of mTBI patients.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalJournal of Neurotrauma
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2017

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Brain Concussion
Stroke
Magnetic Resonance Imaging
Wounds and Injuries
Diffusion Magnetic Resonance Imaging
Traumatic Brain Injury
Brain Injuries
Chronic Disease

Keywords

  • CT scanning
  • MRI
  • TBI

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Trauma-Specific Brain abnormalities in suspected mild traumatic brain injury patients identified in the first 48 hours after injury : A blinded magnetic resonance imaging comparative study including suspected acute minor stroke patients. / Chiara Ricciardi, Maria; Bokkers, Reinoud P H; Butman, John A.; Hammoud, Dima A.; Pham, Dzung L.; Warach, Steven; Latour, Lawrence L.

In: Journal of Neurotrauma, Vol. 34, No. 1, 01.01.2017, p. 23-30.

Research output: Contribution to journalArticle

Chiara Ricciardi, Maria ; Bokkers, Reinoud P H ; Butman, John A. ; Hammoud, Dima A. ; Pham, Dzung L. ; Warach, Steven ; Latour, Lawrence L. / Trauma-Specific Brain abnormalities in suspected mild traumatic brain injury patients identified in the first 48 hours after injury : A blinded magnetic resonance imaging comparative study including suspected acute minor stroke patients. In: Journal of Neurotrauma. 2017 ; Vol. 34, No. 1. pp. 23-30.
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