Traumatic brain injury

Diffusion-weighted MR imaging findings

Amon Y. Liu, Joseph A Maldjian, Linda J. Bagley, Grant P. Sinson, Robert I. Grossman

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Diffuse axonal injury (DAI) accounts for a significant portion of primary intra-axial lesions in cases of traumatic brain injury. The goal of this study was to use diffusion-weighted MR imaging to characterize DAI in the setting of acute and subacute traumatic brain injury. METHODS: Nine patients ranging in age from 26 to 78 years were examined with conventional MR imaging (including fast spin-echo T2-weighted, fluid-attenuated inversion-recovery, and gradient-echo sequences) as well as echo-planar diffusion-weighted MR imaging 1 to 18 days after traumatic injury. Lesions were characterized as DAI on the basis of their location and their appearance on conventional MR images. Trace apparent diffusion coefficient (ADC) maps were computed off-line with the diffusion-weighted and base-line images. Areas of increased signal were identified on the diffusion- weighted images, and regions of interests were used to obtain trace ADC values. RESULTS: In the nine patients studied, isotropic diffusion-weighted images showed areas of increased signal with correspondingly decreased ADC. In one case, decreased ADC was seen 18 days after the initial event. CONCLUSION: Decreased ADC can be demonstrated in patients with DAI in the acute setting and may persist into the subacute period, beyond that described for cytotoxic edema in ischemia.

Original languageEnglish (US)
Pages (from-to)1636-1641
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume20
Issue number9
StatePublished - Nov 4 1999

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Diffuse Axonal Injury
Traumatic Brain Injury
Edema
Ischemia
Wounds and Injuries

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Liu, A. Y., Maldjian, J. A., Bagley, L. J., Sinson, G. P., & Grossman, R. I. (1999). Traumatic brain injury: Diffusion-weighted MR imaging findings. American Journal of Neuroradiology, 20(9), 1636-1641.

Traumatic brain injury : Diffusion-weighted MR imaging findings. / Liu, Amon Y.; Maldjian, Joseph A; Bagley, Linda J.; Sinson, Grant P.; Grossman, Robert I.

In: American Journal of Neuroradiology, Vol. 20, No. 9, 04.11.1999, p. 1636-1641.

Research output: Contribution to journalArticle

Liu, AY, Maldjian, JA, Bagley, LJ, Sinson, GP & Grossman, RI 1999, 'Traumatic brain injury: Diffusion-weighted MR imaging findings', American Journal of Neuroradiology, vol. 20, no. 9, pp. 1636-1641.
Liu AY, Maldjian JA, Bagley LJ, Sinson GP, Grossman RI. Traumatic brain injury: Diffusion-weighted MR imaging findings. American Journal of Neuroradiology. 1999 Nov 4;20(9):1636-1641.
Liu, Amon Y. ; Maldjian, Joseph A ; Bagley, Linda J. ; Sinson, Grant P. ; Grossman, Robert I. / Traumatic brain injury : Diffusion-weighted MR imaging findings. In: American Journal of Neuroradiology. 1999 ; Vol. 20, No. 9. pp. 1636-1641.
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