Treating depression complicated by comorbid medical illness or anxiety.

In this online activity, Trivedi discusses pharmacotherapy treatments for depression in the presence of comorbid medical illness or physical symptoms. The focus is on key aspects of treatment such as remission as the treatment goal, effects of different classes of antidepressants, and benefits of using treatment algorithms. Clayton addresses issues related to comorbid depression and anxiety including prevalence and recognition, risk factors and outcomes, and treatment considerations. Frank highlights the importance of psychotherapy in the treatment of complicated depression, citing empirically validated psychotherapies for acute depressive episodes as well as describing how to apply psychotherapy to medical patients with depression.