Treating mouse and rat tumors with direct current

C. K. Chou, J. A. McDougall, C. Ahn, N. Vora

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In vivo studies were conducted to evaluate the effectiveness of electrochemical treatment on animal tumor models. Radiation-induced fibrosarcoma tumors were subcutaneously implanted on 157 female C3H/HeJ mice. When the tumor diameter reached 10 mm, 2 to 5 platinum electrodes were inserted into the tumor and treated with direct current. Larger fibrosarcomas were implanted on 34 female Fisher 344 rats, which were treated when the tumors reached 20-30 mm in length. In the second group of 24 rats, 12 rats were treated once, 10 twice and two thrice. Best mice cure rate, three months post treatment, calculated by the Kaplan-Meier method, was 59.3% (n=27). For the 24 rats, 6 months post treatment, there were 18 living without tumors (75%). These results indicate that electrochemical treatment is effective on mouse and rate fibrosarcoma tumors.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Editors Anon
Pages631-632
Number of pages2
Volume17
Edition1
Publication statusPublished - 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

Other

OtherProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
CityMontreal, Can
Period9/20/959/23/95

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Chou, C. K., McDougall, J. A., Ahn, C., & Vora, N. (1995). Treating mouse and rat tumors with direct current. In Anon (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (1 ed., Vol. 17, pp. 631-632)