Treating mouse and rat tumors with direct current

In vivo studies were conducted to evaluate the effectiveness of electrochemical treatment on animal tumor models. Radiation-induced fibrosarcoma tumors were subcutaneously implanted on 157 female C3H/HeJ mice. When the tumor diameter reached 10 mm, 2 to 5 platinum electrodes were inserted into the tumor and treated with direct current. Larger fibrosarcomas were implanted on 34 female Fisher 344 rats, which were treated when the tumors reached 20-30 mm in length. In the second group of 24 rats, 12 rats were treated once, 10 twice and two thrice. Best mice cure rate, three months post treatment, calculated by the Kaplan-Meier method, was 59.3% (n=27). For the 24 rats, 6 months post treatment, there were 18 living without tumors (75%). These results indicate that electrochemical treatment is effective on mouse and rate fibrosarcoma tumors.