Treating schizophrenia now and developing strategies for the next decade

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2 Scopus citations


This paper focuses on treatments for schizophrenia (SZ) - treatments we have now and those we hope to have in the future. The treatments we have are based on serendipity, but are effective nonetheless. Pharmacologic characteristics of the most-prescribed drugs are reviewed. It is apparent that a spectrum of effective drugs exist to support individualized therapy. With a view to future discovery, a strategy is proposed for rational antipsychotic drug development. A few concrete examples from the author's own laboratory illustrate an application of the proposal. These data would support the existence of a drug target in the anterior cingulate and/or hippocampal cortex. The studies suggest a focus on the limbic cortex for SZ pathophysiology. It would depend on future discovery to test whether this proposal will be productive. For sure, the rapid advance of basic neuroscience provides untold promise for the future.

Original languageEnglish (US)
Pages (from-to)987-991+1000
JournalCNS spectrums
Issue number12
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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