TY - JOUR
T1 - Treatment of chromophobe adenomas with megavoltage irradiation
AU - Pistenma, David A.
AU - Goffinet, Don R.
AU - Bagshaw, Malcolm A.
AU - Hanbery, John W.
AU - Eltringham, J. R.
PY - 1975/6
Y1 - 1975/6
N2 - From 1956–1972, 62 previously untreated patients with chromophobe adenomas received high‐dose (average equivalent dose: 5700 rads in 6 weeks) megavoltage (4–4.8 MeV) irradiation at Stanford, 33 postoperatively and 29 as the only intended treatment. Initial treatment failure rates were 18% and 41%, respectively; however, overall control was 85% and 90%, despite 2 uncontrolled “invasive” adenomas in each group. Nine of the 12 failures in the group treated by irradiation alone had cystic tumors, and 9 of the 12 “failed” in less than 3 months. Despite a considerably greater degree of abnormal vision initially in the postoperative irradiation group, improvement of vision with treatment in that group was 83% (39% returned to normal) compared to 46% (only 8% to normal) in the irradiation alone group. Based upon an evaluation of the extent of findings at diagnosis and our results, we recommend surgical decompression followed by 5000 rads in 5 weeks for patients with any one or more of the following findings: 1) more than minimal depression of peripheral visual fields; 2) corrected visual actuity of less than 20/30 in either eye; or 3) more than 1‐cm suprasellar extension of tumor. We recommend irradiation alone, as specified, for smaller adenomas accompanied by less extensive or no visual abnormalities.
AB - From 1956–1972, 62 previously untreated patients with chromophobe adenomas received high‐dose (average equivalent dose: 5700 rads in 6 weeks) megavoltage (4–4.8 MeV) irradiation at Stanford, 33 postoperatively and 29 as the only intended treatment. Initial treatment failure rates were 18% and 41%, respectively; however, overall control was 85% and 90%, despite 2 uncontrolled “invasive” adenomas in each group. Nine of the 12 failures in the group treated by irradiation alone had cystic tumors, and 9 of the 12 “failed” in less than 3 months. Despite a considerably greater degree of abnormal vision initially in the postoperative irradiation group, improvement of vision with treatment in that group was 83% (39% returned to normal) compared to 46% (only 8% to normal) in the irradiation alone group. Based upon an evaluation of the extent of findings at diagnosis and our results, we recommend surgical decompression followed by 5000 rads in 5 weeks for patients with any one or more of the following findings: 1) more than minimal depression of peripheral visual fields; 2) corrected visual actuity of less than 20/30 in either eye; or 3) more than 1‐cm suprasellar extension of tumor. We recommend irradiation alone, as specified, for smaller adenomas accompanied by less extensive or no visual abnormalities.
UR - http://www.scopus.com/inward/record.url?scp=0016592063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016592063&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(197506)35:6<1574::AID-CNCR2820350615>3.0.CO;2-B
DO - 10.1002/1097-0142(197506)35:6<1574::AID-CNCR2820350615>3.0.CO;2-B
M3 - Article
C2 - 807313
AN - SCOPUS:0016592063
SN - 0008-543X
VL - 35
SP - 1574
EP - 1582
JO - Cancer
JF - Cancer
IS - 6
ER -