TY - JOUR
T1 - Treatment of experimental chronic pulmonary mycoplasmosis
AU - Fonseca-Aten, Monica
AU - Rios, Ana Maria
AU - Mejias, Asuncion
AU - Chavez-Bueno, Susana
AU - Katz, Kathy
AU - Gomez, Ana Maria
AU - Ramilo, Octavio
AU - McCracken, George H.
AU - Hardy, R. Doug
PY - 2006/9
Y1 - 2006/9
N2 - Mycoplasma pneumoniae infection has been associated with chronic lung disease. Treatment of chronic pulmonary mycoplasmosis has not been well investigated. BALB/c mice were intranasally inoculated once with M. pneumoniae or with sterile media (uninfected controls). Infected mice were treated with telithromycin or placebo daily for 10 days in the chronic phase of disease (18 months after inoculation). Mice (n = 43) were evaluated before therapy and 1 day after completion of telithromycin. Treatment of infected mice with telithromycin at 18 months after infection significantly reduced chronic pulmonary histological inflammation compared with infected mice given placebo; however, this treatment did not improve airway obstruction or airway hyperresponsiveness. Therapy longer than 10 days may be necessary to improve pulmonary function.
AB - Mycoplasma pneumoniae infection has been associated with chronic lung disease. Treatment of chronic pulmonary mycoplasmosis has not been well investigated. BALB/c mice were intranasally inoculated once with M. pneumoniae or with sterile media (uninfected controls). Infected mice were treated with telithromycin or placebo daily for 10 days in the chronic phase of disease (18 months after inoculation). Mice (n = 43) were evaluated before therapy and 1 day after completion of telithromycin. Treatment of infected mice with telithromycin at 18 months after infection significantly reduced chronic pulmonary histological inflammation compared with infected mice given placebo; however, this treatment did not improve airway obstruction or airway hyperresponsiveness. Therapy longer than 10 days may be necessary to improve pulmonary function.
KW - Asthma
KW - Chronic infection
KW - Mycoplasma pneumoniae
KW - Pneumonia
KW - Reactive airway disease
KW - Telithromycin
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U2 - 10.1016/j.ijantimicag.2006.04.008
DO - 10.1016/j.ijantimicag.2006.04.008
M3 - Article
C2 - 16891098
AN - SCOPUS:33747145853
SN - 0924-8579
VL - 28
SP - 253
EP - 258
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 3
ER -