Treatment of Group A Streptococcal Pharyngitis in Children: Results of a Prospective, Randomized Study of Four Antimicrobial Agents

C. M. Ginsburg, G. H. McCracken, J. B. Steinberg, S. D. Crow, B. F. Dildy, F. Cope, T. Zweighaft

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31 Scopus citations


Penicillin V, benzathine/procaine penicillin G, cefadroxil monohydrate, and erythromycin estolate were randomly assigned for therapy of group A streptococcal pharyngitis in 198 children. All patients improved within 24 hours of initiating therapy. Reinfection with a new group A streptococcal serotype occurred in 13 patients, 12 developing 7 to 12 days afrer stopping therapy and 11 becoming symptomatic. Relapse with the same organism oc curred in 16 patients, only 5 (31%) of whom were symptomatic. Antibody titer rises, antibiotic resistance of group A organisms, presence of penicillinase- producing staphylococci, and lack of compliance were not related to re current infections. There were no significant differences between the failure rates of the four test drugs: penicillin V, 12%; benzathine/procaine penicillin G, 12%; cefadroxil monohydrate, 5%; and erythromycin, 2%.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalClinical Pediatrics
Issue number2
StatePublished - Feb 1982


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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