Treatment of Group A streptococcal pharyngitis in children. Results of a prospective, randomized study of four agents

C. M. Ginsburg, G. H. McCracken, J. B. Steinberg, S. D. Crow, B. F. Dildy, F. Cope, T. Zweighaft

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Penicillin V, benzathine/procaine penicillin G, cefadroxil monohydrate, and erythromycin estolate were randomly assigned for therapy of group A streptococcal pharyngitis in 198 children. All patients improved within 24 hours of initiating therapy. Reinfection with a new group A streptococcal serotype occurred in 13 patients, 12 developing 7 to 12 days after stopping therapy and 11 becoming symptomatic. Relapse with the same organism occurred in 16 patients, only 5 (31%) of whom were symptomatic. Antibody titer rises, antibiotic resistance of group A organisms, presence of penicillinase-producing staphylococci, and lack of compliance were not related to recurrent infections. There were no significant differences between the failure rates of the four test drugs: penicillin V, 12%; benzathine/procaine penicillin G, 12%; cefadroxil monohydrate, 5%; and erythromycin, 2%.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalClinical Pediatrics
Volume21
Issue number2
StatePublished - 1982

Fingerprint

Pharyngitis
Cefadroxil
Penicillin G Procaine
Penicillin G Benzathine
Penicillin G
Prospective Studies
Erythromycin Estolate
Penicillin V
Penicillinase
Erythromycin
Microbial Drug Resistance
Group Psychotherapy
Staphylococcus
Compliance
Therapeutics
Recurrence
Antibodies
Infection
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Treatment of Group A streptococcal pharyngitis in children. Results of a prospective, randomized study of four agents. / Ginsburg, C. M.; McCracken, G. H.; Steinberg, J. B.; Crow, S. D.; Dildy, B. F.; Cope, F.; Zweighaft, T.

In: Clinical Pediatrics, Vol. 21, No. 2, 1982, p. 83-88.

Research output: Contribution to journalArticle

Ginsburg, C. M. ; McCracken, G. H. ; Steinberg, J. B. ; Crow, S. D. ; Dildy, B. F. ; Cope, F. ; Zweighaft, T. / Treatment of Group A streptococcal pharyngitis in children. Results of a prospective, randomized study of four agents. In: Clinical Pediatrics. 1982 ; Vol. 21, No. 2. pp. 83-88.
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