Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation

Larry E. Kun, Vincent T. Devita, Robert C. Young, Ralph E. Johnson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A total of 28 patients with previously untreated Hodgkin's disease were treated with combination chemotherapy (MOPP) † Present address: Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A. in full dose followed by radiation therapy. While the relatively small number of patients does not permit comparison of therapeutic efficacy using this sequential approach with previous experience, two other observations warrant special attention. The first is an increased incidence of local and marginal recurrence within irradiation fields (14%). The second and major consideration is the marked enhancement of normal tissue reactions observed. Serious treatment-related morbidity was observed in 15 (54%) of the 28 patients; four of the complications have resulted in death to date with no residual Hodgkin's disease identifiable at autopsy examination.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume1
Issue number7-8
DOIs
StatePublished - Jan 1 1976

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chemotherapy
Hodgkin Disease
Drug Therapy
irradiation
autopsies
Combination Drug Therapy
death
radiation therapy
Autopsy
Radiotherapy
Therapeutics
incidence
examination
Morbidity
Recurrence
dosage
augmentation
Incidence

Keywords

  • Combined irradiation and chemotherapy
  • Hodgkin's disease
  • Post treatment complications

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation. / Kun, Larry E.; Devita, Vincent T.; Young, Robert C.; Johnson, Ralph E.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 1, No. 7-8, 01.01.1976, p. 619-626.

Research output: Contribution to journalArticle

Kun, Larry E. ; Devita, Vincent T. ; Young, Robert C. ; Johnson, Ralph E. / Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation. In: International Journal of Radiation Oncology, Biology, Physics. 1976 ; Vol. 1, No. 7-8. pp. 619-626.
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