Treatment of hodgkin's disease using intensive chemotherapy followed by irradiation

Larry E. Kun, Vincent T. Devita, Robert C. Young, Ralph E. Johnson

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Abstract

A total of 28 patients with previously untreated Hodgkin's disease were treated with combination chemotherapy (MOPP) † Present address: Medical College of Wisconsin, Milwaukee, WI 53226, U.S.A. in full dose followed by radiation therapy. While the relatively small number of patients does not permit comparison of therapeutic efficacy using this sequential approach with previous experience, two other observations warrant special attention. The first is an increased incidence of local and marginal recurrence within irradiation fields (14%). The second and major consideration is the marked enhancement of normal tissue reactions observed. Serious treatment-related morbidity was observed in 15 (54%) of the 28 patients; four of the complications have resulted in death to date with no residual Hodgkin's disease identifiable at autopsy examination.

Original languageEnglish (US)
Pages (from-to)619-626
Number of pages8
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume1
Issue number7-8
DOIs
Publication statusPublished - Jan 1 1976

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Keywords

  • Combined irradiation and chemotherapy
  • Hodgkin's disease
  • Post treatment complications

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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