Treatment of Preterm Labor with the Beta-Adrenergic Agonist Ritodrine

T. J. Benedetti, S. N. Caritis, W. J. Ledger, N. H. Lauersen, J. M. Moutquin, S. B. Effer, J. C. Sinclair, R. S. Sauve, R. A. Milner, K. J. Leveno, F. G. Cunningham

Research output: Contribution to journalLetter

66 Scopus citations

Abstract

To the Editor: In the Canadian study of ritodrine (July 30 issue),1 no mention is made of the power of the study to detect meaningful differences. I have calculated its statistical power for the major outcome variables and have found there to be serious problems with the conclusion reached by both the study authors and the editorialists, Leveno and Cunningham2 — i.e., that there are no significant differences between the treatment groups. The observed mortality in both groups was 6 percent. If there were a true reduction in mortality by 50 percent (from 6 percent to 3 percent) in the…

Original languageEnglish (US)
Pages (from-to)1758-1760
Number of pages3
JournalNew England Journal of Medicine
Volume327
Issue number24
DOIs
StatePublished - Dec 10 1992

ASJC Scopus subject areas

  • Medicine(all)

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    Benedetti, T. J., Caritis, S. N., Ledger, W. J., Lauersen, N. H., Moutquin, J. M., Effer, S. B., Sinclair, J. C., Sauve, R. S., Milner, R. A., Leveno, K. J., & Cunningham, F. G. (1992). Treatment of Preterm Labor with the Beta-Adrenergic Agonist Ritodrine. New England Journal of Medicine, 327(24), 1758-1760. https://doi.org/10.1056/NEJM199212103272414