TY - JOUR
T1 - Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1
AU - Kavanaugh, Arthur F.
AU - Davis, Laurie S.
AU - Nichols, Lisa A.
AU - Norris, Stephen H.
AU - Rothlein, Robert
AU - Scharschmidt, Linda A.
AU - Lipsky, Peter E.
PY - 1994/7
Y1 - 1994/7
N2 - Objective. To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM‐1; CD54) in rheumatoid arthritis (RA). Methods. A phase I/II, open‐label, dose‐escalation study of 32 patients. Results. During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient. Conclusion. Anti—ICAM‐1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RA patients.
AB - Objective. To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM‐1; CD54) in rheumatoid arthritis (RA). Methods. A phase I/II, open‐label, dose‐escalation study of 32 patients. Results. During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient. Conclusion. Anti—ICAM‐1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RA patients.
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U2 - 10.1002/art.1780370703
DO - 10.1002/art.1780370703
M3 - Article
C2 - 7912930
AN - SCOPUS:0028355977
SN - 0004-3591
VL - 37
SP - 992
EP - 999
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 7
ER -