Trefoil factors: Initiators of mucosal healing

Douglas Taupin; Daniel K. Podolsky

doi:10.1038/nrm1203

Trefoil factors: Initiators of mucosal healing

Douglas Taupin, Daniel K. Podolsky

Research output: Contribution to journal › Review article › peer-review

533 Scopus citations

Abstract

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of small, yet abundant, secreted proteins - the trefoil factors (TFFs). TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood.

Original language	English (US)
Pages (from-to)	721-732
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	4
Issue number	9
DOIs	https://doi.org/10.1038/nrm1203
State	Published - Sep 1 2003

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm1203

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Trefoil factors: Initiators of mucosal healing

Abstract

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