Trefoil factors: Initiators of mucosal healing

Douglas Taupin, Daniel K. Podolsky

Research output: Contribution to journalReview articlepeer-review

465 Scopus citations

Abstract

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of small, yet abundant, secreted proteins - the trefoil factors (TFFs). TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood.

Original languageEnglish (US)
Pages (from-to)721-732
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume4
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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