Trefoil factors: Initiators of mucosal healing

Douglas Taupin, Daniel K. Podolsky

Research output: Contribution to journalReview article

443 Scopus citations

Abstract

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of small, yet abundant, secreted proteins - the trefoil factors (TFFs). TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood.

Original languageEnglish (US)
Pages (from-to)721-732
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume4
Issue number9
DOIs
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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