Treprostinil for the treatment of pulmonary arterial hypertension

Fernando Torres, Lewis J. Rubin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease characterized by increasing pulmonary vascular resistance leading to right ventricular failure and death. Treprostinil is a stable prostacyclin analog approved for the treatment of PAH to improve exercise capacity. In the setting of PAH, the major pharmacological actions of treprostinil include vasodilatation of the pulmonary and systemic vascular beds, inhibition of platelet aggregation and inhibition of smooth muscle cell proliferation. Treprostinil therapy may be delivered via parenteral (subcutaneous and intravenous) or inhaled routes of administration, with oral tablets in the later stages of clinical development. In clinical trials, treprostinil has been shown to improve clinical status, functional class, exercise capacity and quality of life. Common side effects of treprostinil therapy include headache, flushing, jaw pain, diarrhea, and for subcutaneous administration, infusion site pain or reaction. This article provides an overview of treprostinil therapy for the treatment of PAH with a focus on the available efficacy and safety data for parenteral, inhaled and oral administration.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalExpert Review of Cardiovascular Therapy
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • prostacyclin
  • prostacyclin analog
  • prostaglandin
  • pulmonary arterial hypertension
  • treprostinil

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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