Triple-negative breast carcinoma in African American and caucasian women: Clinicopathology, immunomarkers, and outcome

Harold C. Sullivan, Gabriela Oprea-Ilies, Amy L. Adams, Andrew J. Page, Sungjin Kim, Jason Wang, Cynthia Cohen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE:: Breast cancers are often classified on the presence/absence of hormone receptors, and growth factor oncogenes (estrogen receptor, progesterone receptor, HER2). Triple-negative breast cancers, negative for these markers, do not benefit from targeted therapy. We compared clinicopathologic parameters and immunohistochemical markers of prognostic and/or predictive significance, and outcome between African American and Caucasian triple-negative breast cancer patients. METHODS:: Invasive triple-negative breast cancers from African American (n=94) and Caucasian (n=68) patients were studied. Clinicopathologic features (age, tumor size, grade, lymph node status, angiolymphatic invasion, visceral metastases) and survival (overall and progression free) were compared. Marker expression (CK5, CK7, CK8, CK14, CK18, CK19, vimentin, CD44, c-Kit, epidermal growth factor receptor, p-cadherin, p53, p63, topoisomerase II, androgen receptor, Ki-67) was assessed in tissue microarrays. RESULTS:: Significant differences between African American and Caucasian women were observed for mean age and tumor size. African Americans had a trend toward greater lymph node involvement than Caucasians. The following markers were found in significantly different frequencies between the 2 groups: CK5, CK8, CK19, c-Kit, androgen receptor, and high Ki-67. African Americans show shorter overall and progression-free survival. Other clinicopathologic parameters, markers, and outcome were present at similar frequencies. DISCUSSION:: African American triple-negative breast cancers were more aggressive, occurring at a younger age, being larger, with higher proliferation, patients more frequently dying of disease, and with a trend toward positive lymph node status. Heterogeneity of marker expression suggests variation in the genetics of breast carcinomas in different races.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalApplied Immunohistochemistry and Molecular Morphology
Volume22
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

African Americans
Triple Negative Breast Neoplasms
Breast Neoplasms
Lymph Nodes
Androgen Receptors
Disease-Free Survival
Proto-Oncogene Proteins c-kit
Somatotropin Receptors
Type II DNA Topoisomerase
Growth Factor Receptors
Vimentin
Progesterone Receptors
Cadherins
Oncogenes
Epidermal Growth Factor Receptor
Estrogen Receptors
Neoplasms
Neoplasm Metastasis

Keywords

  • breast cancer
  • immunohistochemistry
  • triple negative

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Histology

Cite this

Triple-negative breast carcinoma in African American and caucasian women : Clinicopathology, immunomarkers, and outcome. / Sullivan, Harold C.; Oprea-Ilies, Gabriela; Adams, Amy L.; Page, Andrew J.; Kim, Sungjin; Wang, Jason; Cohen, Cynthia.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 22, No. 1, 01.2014, p. 17-23.

Research output: Contribution to journalArticle

Sullivan, Harold C. ; Oprea-Ilies, Gabriela ; Adams, Amy L. ; Page, Andrew J. ; Kim, Sungjin ; Wang, Jason ; Cohen, Cynthia. / Triple-negative breast carcinoma in African American and caucasian women : Clinicopathology, immunomarkers, and outcome. In: Applied Immunohistochemistry and Molecular Morphology. 2014 ; Vol. 22, No. 1. pp. 17-23.
@article{0b9d796fac32410cbfaca80a70962c26,
title = "Triple-negative breast carcinoma in African American and caucasian women: Clinicopathology, immunomarkers, and outcome",
abstract = "PURPOSE:: Breast cancers are often classified on the presence/absence of hormone receptors, and growth factor oncogenes (estrogen receptor, progesterone receptor, HER2). Triple-negative breast cancers, negative for these markers, do not benefit from targeted therapy. We compared clinicopathologic parameters and immunohistochemical markers of prognostic and/or predictive significance, and outcome between African American and Caucasian triple-negative breast cancer patients. METHODS:: Invasive triple-negative breast cancers from African American (n=94) and Caucasian (n=68) patients were studied. Clinicopathologic features (age, tumor size, grade, lymph node status, angiolymphatic invasion, visceral metastases) and survival (overall and progression free) were compared. Marker expression (CK5, CK7, CK8, CK14, CK18, CK19, vimentin, CD44, c-Kit, epidermal growth factor receptor, p-cadherin, p53, p63, topoisomerase II, androgen receptor, Ki-67) was assessed in tissue microarrays. RESULTS:: Significant differences between African American and Caucasian women were observed for mean age and tumor size. African Americans had a trend toward greater lymph node involvement than Caucasians. The following markers were found in significantly different frequencies between the 2 groups: CK5, CK8, CK19, c-Kit, androgen receptor, and high Ki-67. African Americans show shorter overall and progression-free survival. Other clinicopathologic parameters, markers, and outcome were present at similar frequencies. DISCUSSION:: African American triple-negative breast cancers were more aggressive, occurring at a younger age, being larger, with higher proliferation, patients more frequently dying of disease, and with a trend toward positive lymph node status. Heterogeneity of marker expression suggests variation in the genetics of breast carcinomas in different races.",
keywords = "breast cancer, immunohistochemistry, triple negative",
author = "Sullivan, {Harold C.} and Gabriela Oprea-Ilies and Adams, {Amy L.} and Page, {Andrew J.} and Sungjin Kim and Jason Wang and Cynthia Cohen",
year = "2014",
month = "1",
doi = "10.1097/PAI.0b013e318281148e",
language = "English (US)",
volume = "22",
pages = "17--23",
journal = "Applied Immunohistochemistry and Molecular Morphology",
issn = "1541-2016",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Triple-negative breast carcinoma in African American and caucasian women

T2 - Clinicopathology, immunomarkers, and outcome

AU - Sullivan, Harold C.

AU - Oprea-Ilies, Gabriela

AU - Adams, Amy L.

AU - Page, Andrew J.

AU - Kim, Sungjin

AU - Wang, Jason

AU - Cohen, Cynthia

PY - 2014/1

Y1 - 2014/1

N2 - PURPOSE:: Breast cancers are often classified on the presence/absence of hormone receptors, and growth factor oncogenes (estrogen receptor, progesterone receptor, HER2). Triple-negative breast cancers, negative for these markers, do not benefit from targeted therapy. We compared clinicopathologic parameters and immunohistochemical markers of prognostic and/or predictive significance, and outcome between African American and Caucasian triple-negative breast cancer patients. METHODS:: Invasive triple-negative breast cancers from African American (n=94) and Caucasian (n=68) patients were studied. Clinicopathologic features (age, tumor size, grade, lymph node status, angiolymphatic invasion, visceral metastases) and survival (overall and progression free) were compared. Marker expression (CK5, CK7, CK8, CK14, CK18, CK19, vimentin, CD44, c-Kit, epidermal growth factor receptor, p-cadherin, p53, p63, topoisomerase II, androgen receptor, Ki-67) was assessed in tissue microarrays. RESULTS:: Significant differences between African American and Caucasian women were observed for mean age and tumor size. African Americans had a trend toward greater lymph node involvement than Caucasians. The following markers were found in significantly different frequencies between the 2 groups: CK5, CK8, CK19, c-Kit, androgen receptor, and high Ki-67. African Americans show shorter overall and progression-free survival. Other clinicopathologic parameters, markers, and outcome were present at similar frequencies. DISCUSSION:: African American triple-negative breast cancers were more aggressive, occurring at a younger age, being larger, with higher proliferation, patients more frequently dying of disease, and with a trend toward positive lymph node status. Heterogeneity of marker expression suggests variation in the genetics of breast carcinomas in different races.

AB - PURPOSE:: Breast cancers are often classified on the presence/absence of hormone receptors, and growth factor oncogenes (estrogen receptor, progesterone receptor, HER2). Triple-negative breast cancers, negative for these markers, do not benefit from targeted therapy. We compared clinicopathologic parameters and immunohistochemical markers of prognostic and/or predictive significance, and outcome between African American and Caucasian triple-negative breast cancer patients. METHODS:: Invasive triple-negative breast cancers from African American (n=94) and Caucasian (n=68) patients were studied. Clinicopathologic features (age, tumor size, grade, lymph node status, angiolymphatic invasion, visceral metastases) and survival (overall and progression free) were compared. Marker expression (CK5, CK7, CK8, CK14, CK18, CK19, vimentin, CD44, c-Kit, epidermal growth factor receptor, p-cadherin, p53, p63, topoisomerase II, androgen receptor, Ki-67) was assessed in tissue microarrays. RESULTS:: Significant differences between African American and Caucasian women were observed for mean age and tumor size. African Americans had a trend toward greater lymph node involvement than Caucasians. The following markers were found in significantly different frequencies between the 2 groups: CK5, CK8, CK19, c-Kit, androgen receptor, and high Ki-67. African Americans show shorter overall and progression-free survival. Other clinicopathologic parameters, markers, and outcome were present at similar frequencies. DISCUSSION:: African American triple-negative breast cancers were more aggressive, occurring at a younger age, being larger, with higher proliferation, patients more frequently dying of disease, and with a trend toward positive lymph node status. Heterogeneity of marker expression suggests variation in the genetics of breast carcinomas in different races.

KW - breast cancer

KW - immunohistochemistry

KW - triple negative

UR - http://www.scopus.com/inward/record.url?scp=84891743555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891743555&partnerID=8YFLogxK

U2 - 10.1097/PAI.0b013e318281148e

DO - 10.1097/PAI.0b013e318281148e

M3 - Article

C2 - 23455177

AN - SCOPUS:84891743555

VL - 22

SP - 17

EP - 23

JO - Applied Immunohistochemistry and Molecular Morphology

JF - Applied Immunohistochemistry and Molecular Morphology

SN - 1541-2016

IS - 1

ER -