trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

Lino Tessarollo, Pantelis Tsoulfas, Dionisio Martin-Zanca, Debra J. Gilbert, Nancy A. Jenkins, Neal G. Copeland, Luis F. Parada

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells. Direct comparison with trk and trkB developmental expression patterns permits the following observations. (1) trkC is expressed in novel neural tissues where other Trk genes are silent. (2) Some tissues appear to coexpress trkB and trkC receptors in the embryo and in the adult. (3) trkC expression can be detected in the gastrulating embryo. These data provide insights into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Finally, interspecific mouse backcrosses have been used to map the location of each of the TrA: genes on mouse chromosomes. Alignment with available chromosomal maps identify possible linkage between the TrA genes and known neurological mutations.

Original languageEnglish (US)
Pages (from-to)463-475
Number of pages13
JournalDevelopment
Volume118
Issue number2
StatePublished - Jun 1993

Fingerprint

trkC Receptor
Neurotrophin 3
Nervous System
Nerve Growth Factor Receptors
Nerve Growth Factors
Genes
Embryonic Structures
trkB Receptor
Receptor Protein-Tyrosine Kinases
Nerve Growth Factor
Chromosomes
Mutation

Keywords

  • Mouse nervous system
  • Neural development, neurotrophin
  • NT-3
  • trkC
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

Cite this

Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., & Parada, L. F. (1993). trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development, 118(2), 463-475.

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. / Tessarollo, Lino; Tsoulfas, Pantelis; Martin-Zanca, Dionisio; Gilbert, Debra J.; Jenkins, Nancy A.; Copeland, Neal G.; Parada, Luis F.

In: Development, Vol. 118, No. 2, 06.1993, p. 463-475.

Research output: Contribution to journalArticle

Tessarollo, L, Tsoulfas, P, Martin-Zanca, D, Gilbert, DJ, Jenkins, NA, Copeland, NG & Parada, LF 1993, 'trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues', Development, vol. 118, no. 2, pp. 463-475.
Tessarollo L, Tsoulfas P, Martin-Zanca D, Gilbert DJ, Jenkins NA, Copeland NG et al. trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development. 1993 Jun;118(2):463-475.
Tessarollo, Lino ; Tsoulfas, Pantelis ; Martin-Zanca, Dionisio ; Gilbert, Debra J. ; Jenkins, Nancy A. ; Copeland, Neal G. ; Parada, Luis F. / trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. In: Development. 1993 ; Vol. 118, No. 2. pp. 463-475.
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