Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus

Mercedes Cueto, John B. MacMillan, Paul R. Jensen, William Fenical

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Four cytotoxic meroterpenoids, tropolactones A-D, were isolated from the whole broth extract of a marine-derived fungus of the genus Aspergillus. The structures of the meroterpenoids were established through a variety of two-dimensional NMR techniques. The absolute configuration of tropolactone A was determined using the modified Mosher method. Tropolactones A-C contain an interesting substituted 2,4,6-cycloheptatriene (tropone) ring, which presumably arises through an oxidative ring expansion from tropolactone D. Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 μg/mL.

Original languageEnglish (US)
Pages (from-to)1826-1831
Number of pages6
JournalPhytochemistry
Volume67
Issue number16
DOIs
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

Fingerprint Dive into the research topics of 'Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus'. Together they form a unique fingerprint.

  • Cite this