TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.

L. Ye, Sandra Kleiner, Jun Wu, Rajan Sah, Rana K Gupta, Alexander S. Banks, Paul Cohen, Melin J. Khandekar, Pontus Boström, Rina J. Mepani, Dina Laznik, Theodore M. Kamenecka, Xinyi Song, Wolfgang Liedtke, Vamsi K. Mootha, Pere Puigserver, Patrick R. Griffin, David E. Clapham, Bruce M. Spiegelman

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

PGC1α is a key transcriptional coregulator of oxidative metabolism and thermogenesis. Through a high-throughput chemical screen, we found that molecules antagonizing the TRPVs (transient receptor potential vanilloid), a family of ion channels, induced PGC1α expression in adipocytes. In particular, TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. Mice with a null mutation for TRPV4 or wild-type mice treated with a TRPV4 antagonist showed elevated thermogenesis in adipose tissues and were protected from diet-induced obesity, adipose inflammation, and insulin resistance. This role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes could offer a target for treating obesity and related metabolic diseases.

Original languageEnglish (US)
Pages (from-to)96-110
Number of pages15
JournalCell
Volume151
Issue number1
StatePublished - Sep 28 2012

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Thermogenesis
Adipocytes
Metabolism
Energy Metabolism
Insulin Resistance
Homeostasis
Obesity
Insulin
Cell Respiration
Inflammation
TRPV Cation Channels
Metabolic Diseases
Nutrition
Ion Channels
Adipose Tissue
Genes
Throughput
Tissue
Diet
Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ye, L., Kleiner, S., Wu, J., Sah, R., Gupta, R. K., Banks, A. S., ... Spiegelman, B. M. (2012). TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell, 151(1), 96-110.

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. / Ye, L.; Kleiner, Sandra; Wu, Jun; Sah, Rajan; Gupta, Rana K; Banks, Alexander S.; Cohen, Paul; Khandekar, Melin J.; Boström, Pontus; Mepani, Rina J.; Laznik, Dina; Kamenecka, Theodore M.; Song, Xinyi; Liedtke, Wolfgang; Mootha, Vamsi K.; Puigserver, Pere; Griffin, Patrick R.; Clapham, David E.; Spiegelman, Bruce M.

In: Cell, Vol. 151, No. 1, 28.09.2012, p. 96-110.

Research output: Contribution to journalArticle

Ye, L, Kleiner, S, Wu, J, Sah, R, Gupta, RK, Banks, AS, Cohen, P, Khandekar, MJ, Boström, P, Mepani, RJ, Laznik, D, Kamenecka, TM, Song, X, Liedtke, W, Mootha, VK, Puigserver, P, Griffin, PR, Clapham, DE & Spiegelman, BM 2012, 'TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.', Cell, vol. 151, no. 1, pp. 96-110.
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110.
Ye, L. ; Kleiner, Sandra ; Wu, Jun ; Sah, Rajan ; Gupta, Rana K ; Banks, Alexander S. ; Cohen, Paul ; Khandekar, Melin J. ; Boström, Pontus ; Mepani, Rina J. ; Laznik, Dina ; Kamenecka, Theodore M. ; Song, Xinyi ; Liedtke, Wolfgang ; Mootha, Vamsi K. ; Puigserver, Pere ; Griffin, Patrick R. ; Clapham, David E. ; Spiegelman, Bruce M. / TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. In: Cell. 2012 ; Vol. 151, No. 1. pp. 96-110.
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