Trust in Physicians and Regional Brain Volumes: A Population-Based Study

Mohona Sadhu, Bayan Jalalizadeh, Andrew Fritz, Theresa de Freitas Nicholson, Rogelio Garcia, Susana Lampley, Marian Rain, Erin Van Enkevort, E. Sherwood Brown

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: Trust, a fundamental part of human interpersonal relationships, is known to be associated with specific brain regions and demographic characteristics. Level of trust in medical professionals can alter population health outcomes and influence the nature of the doctor-patient relationship. This study utilized structural magnetic resonance imaging (MRI) and trust data from the Dallas Heart Study (DHS), a large community-based study, to determine brain regions associated with degree of trust in physicians and the medical profession. The first phase of the DHS was conducted from 2000 to 2002 and the second phase from 2007 to 2009. Methods: The MRI data were analyzed as part of the DHS using automated FreeSurfer software. Forward stepwise binary logistic regression was performed to investigate the association between measures of trust and bilateral brain region volumes and thickness followed by confirmatory multiple regressions of significant brain regions. A total of 1,596 participants were included in the final analysis. Results: Left caudal anterior cingulate cortex (ACC) thickness was inversely correlated with trust of physicians (P < .01). There were no significant associations between trust in physicians and age, race or ethnicity, or education. Conclusions: The ACC is an integral part of the salience network, the brain network responsible for communication and social behavior. Trust in physicians did not appear to be influenced by demographic characteristics. The findings suggest there are neuroanatomical correlates of trust in physicians.

Original languageEnglish (US)
JournalThe primary care companion for CNS disorders
Issue number5
StatePublished - Oct 17 2019

ASJC Scopus subject areas

  • Medicine(all)


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